“The reason I write this is because I made a switch to daytime LDN dosing after 3 months of night time as a trial for a female(menses) problem I was experiencing due to the LDN.

I have chronic progressive Multiple Sclerosis(Progressive/Relapsing). Bernard .Bihari, MD, told me that for me to get the best boost in endorphins, enough to halt the progession of my type MS, it was best to do the night dosing.

He was correct, on daytime dosing my MS came back to life and I was nearing having to use a wheelchair again. I quickly switched back to night dosing and all is great again. I eventually got the female(Menses) problem under control with other alternative means.

I've been on LDN 5 1/2 years (since July, 2003) and my MS is in remission.

If my grandma(age 90) gets her LDN too early, say 7 or 8 pm, her Alzheimer's symptoms are much worse than if she gets her dose at 10 pm during Daylight Saving Time and 9 pm off DST. The DST thing really does make a difference and my grandma's a great one for testing this.

My grandma's got advanced Alzheimer's as well as cancer and when her LDN is not administered properly by my aunt, it's quite noticeable.

Dr. Bihari insisted my mom take LDN at night due to her breast cancer being an aggressive type, Grade III, Poorly Differentiated, Infiltrating(Invasive) Duct Cell Adenocarcinoma. Hormone receptors...Estrogen=Negative, Progesterone=Negative, HER-2-NEU Oncogene=Negative Over-expression.

Dr. Bihari said my mom needed the endorphin blockade to take place during the 2am to 4am time frame. Mom's been breast cancer free 5 years(April 2004) on LDN, she refused chemo.

My grandma's squamous cell carcinoma tumor was surgically removed Dec 2005 and cancer has not returned. My grandma started LDN Aug 2005, her Alzheimer's has stayed stable since going on LDN, she's 90. She has had some setbacks at times when LDN had to be discontinued for surgeries but once LDN is administered to her she goes back to the previous state before the LDN was stopped.

May 4th, 2009 my mom had bloodtest done for cancer. It came back fantastic, no signs of cancer. Doctor says her bloodwork cannot be anymore perfect. She's now been moved to annual checks. Breast cancer free now 5 years.
                                                    Brenda”
Brenda’s LDN forum